Benzalkonium chloride interferes. Berg OH. Allergy. AZOPTIC contains the preservative benzalkonium chloride. Responses to Benzalkonium Chloride Unsafe in Any Product. That preservative is benzalkonium chloride. The results from your patch testing showed a positive reaction contact allergy to Benzalkonium Chloride. Other names you may see this preservative Parasterol. Benzalkonium chloride is quaternary ammonium compound used in the pharmaceutical industry as an antimicrobial preservative, antiseptic, disinfectant, solubilizing agent, and wetting agent. It is a widely used preservative often found in ophthalmic solutions and contact lens solutions. CMSImagesContent/2017/04/065_ro0417_f5a.jpg' alt='Benzalkonium Chloride Preservative Allergy Diet' title='Benzalkonium Chloride Preservative Allergy Diet' />Benzalkonium chloride Wikipedia. Benzalkonium chloride. Names. Other names. N Alkyl N benzyl N,N dimethylammonium chloride Alkyldimethylbenzylammonium chloride ADBAC BC5. BC8. 0 Quaternary ammonium compounds quats. Identifiers. Ch. EBIECHA Info. Card. 10. 0. 0. 58. EC Number. 26. 4 1. KEGGRTECS number. BO3. 15. 00. 00. UNIIPropertiesvariable. Molar massvariable. Benzalkonium Chloride Preservative Allergy Diet' title='Benzalkonium Chloride Preservative Allergy Diet' />Appearance. Solutions BC5. BC8. Density. 0. 9. 8 gcm. In food industry, benzalkonium chloride that is a quaternary ammonium compound. Pharmacology. D0. AJ0. 1 WHOHazards. OPTH-63790-T01.png' alt='Benzalkonium Chloride Preservative Allergy Diet' title='Benzalkonium Chloride Preservative Allergy Diet' />C, N 1R phrasesoutdatedR2. R3. 4, R5. 01S phrasesoutdatedS2, S3. S4. 5, S6. 11NFPA 7. Flash point. 25. 0 C 4. F 5. 23 K if solvent basedExcept where otherwise noted, data are given for materials in their standard state at 2. C 7. 7 F, 1. 00 k. Pa. N verify what is YN Infobox references. Benzalkonium chloride, also known as BZK, BKC, BAC, alkyldimethylbenzylammonium chloride and ADBAC, is a type of cationic surfactant. It is an organic salt classified as a quaternary ammonium compound. It has three main categories of use as a biocide, a cationicsurfactant, and as a phase transfer agent. ADBACs are a mixture of alkylbenzyldimethylammonium chlorides, in which the alkyl group has various even numbered alkyl chain lengths. Solubility and physical propertieseditDepending on purity, benzalkonium chloride ranges from colourless to a pale yellow impure. Benzalkonium chloride is readily soluble in ethanol and acetone. Although dissolution in water is slow, aqueous solutions are easier to handle and are preferred. Aqueous solutions should be neutral to slightly alkaline. Solutions foam when shaken. Concentrated solutions have a bitter taste and a faint almond like odour. Standard concentrates are manufactured as 5. BC5. 0, BC8. 0, BAC5. Topical+Decongestant+Sprays.jpg' alt='Benzalkonium Chloride Preservative Allergy Diet' title='Benzalkonium Chloride Preservative Allergy Diet' />BAC8. The 5. Cationic surfactanteditBenzalkonium chloride also possesses surfactant properties, dissolving the lipid phase of the tear film and increasing drug penetration, making it a useful excipient. Laundry detergents and treatments. Softeners for textiles. Phase transfer agenteditBenzalkonium chloride is a mainstay of phase transfer catalysis, an important technology in the synthesis of organic compounds, including drugs. Bioactive agentseditEspecially for their antimicrobial activity, benzalkonium chloride is an active ingredient in many consumer products Pharmaceutical products such as eye, ear and nasal drops or sprays, as a preservative. Personal care products such as hand sanitizers, wet wipes, shampoos, deodorants and cosmetics. Skin antiseptics, such as Bactine and Dettol. Some disinfectant solutions, such as post piercing ear disinfectants. Throat lozenges4 and mouthwashes, as a biocide. Spermicidal creams. Over the counter single application treatments for herpes, cold sores, and fever blisters, such as RELEEV and Viroxyn. Burn and ulcer treatment. Spray disinfectants for hard surface sanitization. Cleaners for floor and hard surfaces as a disinfectant, such as Lysol. Algaecides for clearing of algae, moss, lichens from paths, roof tiles, swimming pools, masonry, etc. Benzalkonium chloride is also used in many non consumer processes and products, including as an active ingredient in surgical disinfection. A comprehensive list of uses includes industrial applications. An advantage of benzalkonium chloride, not shared by ethanol based antiseptics or hydrogen peroxide antiseptic, is that it does not cause a burning sensation when applied to broken skin. MedicineeditBenzalkonium chloride is a frequently used preservative in eye drops typical concentrations range from 0. Stronger concentrations can be caustic6 and cause irreversible damage to the corneal endothelium. Avoiding the use of benzalkonium chloride solutions while contact lenses are in place is discussed in the literature. Adverse effectseditAlthough historically benzalkonium chloride has been ubiquitous as a preservative in ophthalmic preparations, its ocular toxicity and irritant properties,1. Many mass marketed inhaler and nasal spray formulations contain benzalkonium chloride as a preservative, despite substantial evidence that it can adversely affect ciliary motion, mucociliary transport, nasal mucosal histology, human neutrophil function, and leukocyte response to local inflammation. Although some studies have found no correlation between use of benzalkonium chloride in concentrations at or below 0. In the United States, nasal steroid preparations that are free of benzalkonium chloride include budesonide, triamcinolone acetonide, dexamethasone, and Beconase and Vancenase aerosol inhalers. Benzalkonium chloride is irritant to middle ear tissues at typically used concentrations. Inner ear toxicity has been demonstrated. Occupational exposure to benzalkonium chloride has been linked to the development of asthma. Counter Strike 1.6 Cheat Headshot. In 2. 01. 1, a large clinical trial designed to evaluate the efficacy of hand sanitizers based on different active ingredients in preventing virus transmission amongst schoolchildren was re designed to exclude sanitizers based on benzalkonium chloride due to safety concerns. Benzalkonium chloride has been in common use as a pharmaceutical preservative and antimicrobial since the 1. While early studies confirmed the corrosive and irritant properties of benzalkonium chloride, investigations into the adverse effects of, and disease states linked to, benzalkonium chloride have only surfaced during the past 3. Benzalkonium chloride is classed as a Category III antiseptic active ingredient by the United States Food and Drug Administration. Ingredients are categorised as Category III when available data are insufficient to classify as safe and effective, and further testing is required. Proxima Nova Bold Font. Benzalkonium chloride is excluded from the current United States Food and Drug Administration review of the safety and effectiveness of consumer antiseptics and topical antimicrobial over the counter drug products, meaning it will remain a Category III ingredient. There is acknowledgement that more data are required on its safety, efficacy and effectiveness, especially with relation to Human pharmacokinetic studies, including information on its metabolites. Studies on animal absorption, distribution, metabolism, and excretion. Data to help define the effect of formulation on dermal absorption. Carcinogenicity. Studies on developmental and reproductive toxicology. Potential hormonal effects. Assessment of the potential for development of bacterial resistance. ToxicologyeditRTECS lists the following acute toxicity data 1. Organism. Route of exposure. Dose LD5. 0Rat. Intravenous. Rat. Oral. 24. 0 mgkg. Rat. Intraperitoneal. Rat. Subcutaneous. Mouse. Subcutaneous. Benzalkonium chloride is a human skin and severe eye irritant. It is a suspected respiratory toxicant, immunotoxicant, gastrointestinal toxicant and neurotoxicant. Benzalkonium chloride formulations for consumer use are dilute solutions. Concentrated solutions are toxic to humans, causing corrosionirritation to the skin and mucosa, and death if taken internally in sufficient volumes. Poisoning by benzalkonium chloride is recognised in the literature. A 2. 01. 4 case study detailing the fatal ingestion of up to 8.